Autoantibodies Associated with Congenital Heart Block
نویسندگان
چکیده
منابع مشابه
Correlation of Maternal Autoantibodies with Fetal Congenital Heart Block.
BACKGROUND Autoimmune fetal congenital heart block (CHB) is the most severe manifestation of neonatal lupus, and it is seen when maternal autoimmune antibodies cross the placenta and damage the AV node of the fetus. CHB is mainly associated with maternal SLE with anti-Ro/SSA- and anti-La/SSB-positive status, and incidence of CHB increases when both the antibodies are present. This study was con...
متن کاملPathophysiology of autoimmune-associated congenital heart block
Congenital heart block (CHB), detected at or before birth, in a structurally normal heart, is strongly associated with autoantibodies to SSA/Ro-SSB/La ribonucleoproteins. The historical hallmark of CHB is complete atrioventricular block (AVB) which is irreversible. CHB occurs in 2% of primigravid mothers with anti-Ro/La antibodies, and in 20% of women who had a previous CHB offspring. Although ...
متن کاملComplete Congenital Heart Block in a Neonatal Lupus Erythematosus Associated with Pulmonary Involvement without Pacemaker Implantation: A Case Report
Background: Neonatal lupus erythematosus is an uncommon disease. Congenital complete heart block (CCHB) usually happens in neonates with maternal systemic lupus erythematosus. The most prevalent presentation of CCHBis bradycardiathatcanbediagnosed through an electrocardiogram. Case report: Here in, we present the case of a full-term male neonate with gestational age of 37 weeks and birth weigh...
متن کاملCongenital heart block associated with Sjögren syndrome: case report
BACKGROUND Congenital heart block is a rare complication of pregnancy associated with Sjögren Syndrome that may result in the death of the foetus or infant, or the need for pacing in the newborn or at a later stage. CASE REPORT The case is presented of a 64-year-old patient with primary Sjögren Syndrome and a history of having given birth to two sons with congenital heart block, both of whom ...
متن کاملAnti-Ro/SSA autoantibodies over time in mothers of children with congenital complete heart block.
Sir, It is commonly assumed that the titer of antiRo/SSA antibodies remains stable over the years, but data in the literature are scanty (14). Congenital heart block (CHB) is a multidisciplinary field; although anti-Ro/SSA antibodies appear to be pathogenically linked to it (5-7), the cardiological literature often describes CHB mothers presumed to be antiRo/SSA negative (8). The aim of this st...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2010
ISSN: 0300-9475
DOI: 10.1111/j.1365-3083.2010.02442.x